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Electronic Control of Ca2+ Signalling in Neuronal Cells using an Organic Electronic Ion Pump
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-2773-5096
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2007 (English)In: Nature Materials, ISSN 1476-1122, Vol. 6, no 9, 673-679 p.Article in journal (Refereed) Published
Abstract [en]

Cells and tissues use finely regulated ion fluxes for their intra- and intercellular communication. Technologies providing spatial and temporal control for studies of such fluxes are however, limited. We have developed an electrophoretic ion pump made of poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulphonate) (PEDOT:PSS) to mediate electronic control of the ion homeostasis in neurons. Ion delivery from a source reservoir to a receiving electrolyte via a PEDOT:PSS thin-film channel was achieved by electronic addressing. Ions are delivered in high quantities at an associated on/off ratio exceeding 300. This induces physiological signalling events that can be recorded at the single-cell level. Furthermore, miniaturization of the device to a 50-um-wide channel allows for stimulation of individual cells. As this technology platform allows for electronic control of ion signalling in individual cells with proper spatial and temporal resolution, it will be useful in further studies of communication in biological systems.

Place, publisher, year, edition, pages
2007. Vol. 6, no 9, 673-679 p.
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-14644DOI: 10.1038/nmat1963OAI: oai:DiVA.org:liu-14644DiVA: diva2:24084
Available from: 2008-11-12 Created: 2008-11-12 Last updated: 2017-02-03
In thesis
1. Organic Bioelectronics: Electrochemical Devices using Conjugated Polymers
Open this publication in new window or tab >>Organic Bioelectronics: Electrochemical Devices using Conjugated Polymers
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Since the Nobel Prize awarded discovery that some polymers or “plastics” can be made electronically conducting, the scientific field of organic electronics has arisen. The use of conducting polymers in electronic devices is appealing, because the materials can be processed from a liquid phase, much like ordinary non-conducting plastics. This gives the opportunity to utilize printing technologies and manufacture electronics roll-to-roll on flexible substrates, ultimately at very low costs. Even more intriguing are the possibilities to achieve completely novel functionalities in combination with the inherent compatibility of these materials with biological species. Therefore, organic electronics can be merged with biology and medicine to create organic bioelectronics, i.e. organic electronic devices that interact with biological samples directly or are used for biological applications.

This thesis aims at giving a background to the field of organic bioelectronics and focuses on how electrochemical devices may be utilized. An organic electronic wettability switch that can be used for lab-on-a-chip applications and control of cell growth as well as an electrochemical ion pump for cell communication and drug delivery are introduced. Furthermore, the underlying electrochemical structures that are the basis for the above mentioned devices, electrochemical display pixels etc. are discussed in detail. In summary, the work contributes to the understanding of electrochemical polymer electronics and, by presenting new bioelectronic inventions, builds a foundation for future projects and discoveries.

Place, publisher, year, edition, pages
Institutionen för teknik och naturvetenskap, 2007
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1128
National Category
Materials Engineering
Identifiers
urn:nbn:se:liu:diva-9679 (URN)978-91-85831-03-6 (ISBN)
Public defence
2007-10-26, K3, Kåkenhus, Campus Norrköping, Norrköping, 10:00 (English)
Opponent
Supervisors
Available from: 2007-10-03 Created: 2007-10-03 Last updated: 2017-02-03

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Isaksson, JoakimNilsson, DavidRobinson, NathanielBerggren, Magnus

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