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Serum amyloid A and protein AA: Molecular mechanisms of a transmissible amyloidosis
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
Uppsala University.
2009 (English)In: FEBS Letters, ISSN 0014-5793, Vol. 583, no 16, 2685-2690 p.Article in journal (Refereed) Published
Abstract [en]

Systemic AA-amyloidosis is a complication of chronic inflammatory diseases and the fibril protein AA derives from the acute phase reactant serum AA. AA-amyloidosis can be induced in mice by an inflammatory challenge. The lag phase before amyloid develops can be dramatically shortened by administration of a small amount of amyloid fibrils. Systemic AA-amyloidosis is transmissible in mice and may be so in humans. Since transmission can cross species barriers it is possible that AA-amyloidosis can be induced by amyloid in food, e.g. foie gras. In mice, development of AA-amyloidosis can also be accelerated by other components with amyloid-like properties. A new possible risk factor may appear with synthetically made fibrils from short peptides, constructed for tissue repair.

Place, publisher, year, edition, pages
2009. Vol. 583, no 16, 2685-2690 p.
Keyword [en]
Amyloid; Fibril; Prion; Seeding; Transmission
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-21254DOI: 10.1016/j.febslet.2009.04.026OAI: diva2:241030
Available from: 2009-09-30 Created: 2009-09-30 Last updated: 2009-09-30

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Westermark, Gunilla
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