liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Systemic reduction of functionally suppressive CD4dimCD25highFoxp3+ T-regs in human second trimester pregnancy is induced by progesterone and 17 beta-estradiol
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology . Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology . Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology . Linköping University, Faculty of Health Sciences.
Show others and affiliations
2009 (English)In: Journal of Reproductive Immunology(ISSN 0165-0378), vol 81, issue 2, 2009, Vol. 81, no 2, 160-161 p.Conference paper, Published paper (Refereed)
Abstract [en]

CD4+CD25high regulatory T cells (Tregs) are implicated in maintenance of murine pregnancy. However, reports regarding circulating Treg frequencies in human pregnancy are inconsistent and the functionality and phenotype of these cells in pregnancy have not been clarified. The aim was to determine the frequency, phenotype and function of circulating Tregs in second trimester human pregnancy and the influence of progesterone and 17β-estradiol on Treg phenotype and frequency. Based on expression of Foxp3, CD127 and HLA-DR, as determined by multi-color flow cytometry, we defined a proper CD4dimCD25high Treg population and showed, in contrast to most previous reports, that this population was reduced in second trimester pregnancy. Unexpectedly, Foxp3 expression was decreased in the Treg, as well as in the CD4+ population. These changes could be replicated in an in vitro system resembling the pregnancy hormonal milieu, where 17β-estradiol, and in particular progesterone, induced, in line with the pregnancy situation, a reduction of CD4dimCD25highFoxp3+ cells in PBMC from non-pregnant women. By co-culturing FACS-sorted Tregs and autologous CD4+CD25- responder cells, we showed that Tregs from pregnant women still displayed the same suppressive capacity as non-pregnant women in terms of suppressing IL-2, TNF-α and IFN-γ secretion from responder cells while efficiently producing IL-4 and IL-10. Our findings support the view of hormones, particularly progesterone, as critical regulators of Tregs in pregnancy. Further, we suggest that in the light of the results of this study, early data on circulating Treg frequencies in pregnancy need re-evaluation.

Place, publisher, year, edition, pages
2009. Vol. 81, no 2, 160-161 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-21510DOI: 10.1016/j.jri.2009.06.225OAI: oai:DiVA.org:liu-21510DiVA: diva2:241461
Note
Original Publication: Jenny Mjösberg, J Svensson, E Johansson, L Hellstrom, Rosaura Casas, Maria Jenmalm, R Boij, L Matthiesen, Jan-Ingvar Jönsson, Göran Berg and Jan Ernerudh, Systemic reduction of functionally suppressive CD4dimCD25highFoxp3+ Tregs in human second trimester pregnancy is induced by progesterone and 17 beta-estradiol, 2009, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, (81), 2, 160-161. http://dx.doi.org/10.1016/j.jri.2009.06.225 Copyright: Elsevier Science B.V., Amsterdam. http://www.elsevier.com/ Available from: 2009-10-02 Created: 2009-10-02 Last updated: 2010-05-19

Open Access in DiVA

fulltext(630 kB)439 downloads
File information
File name FULLTEXT01.pdfFile size 630 kBChecksum SHA-512
3b158944004b65c6924cd0de78996782f01b1c87b7c6b276327ab3d7a4b4d12122cbbaae852cb129b4e31b8372270230495a73b26a05039ac359234564fa8261
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Mjösberg, JennyCasas, RosauraJenmalm, MariaJönsson, Jan-IngvarBerg, GöranErnerudh, Jan

Search in DiVA

By author/editor
Mjösberg, JennyCasas, RosauraJenmalm, MariaJönsson, Jan-IngvarBerg, GöranErnerudh, Jan
By organisation
Department of Clinical and Experimental MedicineFaculty of Health SciencesClinical Immunology Pediatrics Experimental Hematology Obstetrics and gynecology Department of Gynecology and Obstetrics in LinköpingDepartment of Clinical Immunology and Transfusion Medicine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 439 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 227 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf