Decision-anaytical model with lifetime estimation of costs and health outcomes for one-time screening for abdominal aortic aneursm in 65-year-old men
2005 (English)In: British Journal of Surgery, ISSN 0007-1323 (print), 1365-2168 (online), Vol. 92, no 8, 976-983 p.Article in journal (Refereed) Published
Background: Abdominal aortic aneurysm (AAA) causes about 2 per cent of all deaths in men over the age of 65 years. A major improvement in operative mortality would have little impact on total mortality, so screening for AAA has been recommended as a solution. The cost-effectiveness of a programme that invited 65-year-old men for ultrasonographic screening was compared with current clinical practice in a decision-analytical model.
Methods: In a probabilistic Markov model, costs and health outcomes of a screening programme and current clinical practice were simulated over a lifetime perspective. To populate the model with the best available evidence, data from published papers, vascular databases and primary research were used.
Results: The results of the base-case analysis showed that the incremental cost per gained life-year for a screening programme compared with current practice was €7760, and that for a quality-adjusted life-year was €9700. The probability of screening being cost-effective was high.
Conclusion: A financially and practically feasible screening programme for AAA, in which men are invited for ultrasonography in the year in which they turn 65, appears to yield positive health outcomes at a reasonable cost.
Place, publisher, year, edition, pages
2005. Vol. 92, no 8, 976-983 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-14658DOI: 10.1002/bjs.5122OAI: oai:DiVA.org:liu-14658DiVA: diva2:24157