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Plant-Derived Substances as ACE Inhibitors - Biosynthesis-Activity Relationship of Flavonoids, Terpenes and Sterols on Angiotensin-Converting Enzyme Activity in Human Endothelial Cells
Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences.
2009 (English)In: Angiotensin Converting Enzyme Inhibitors, Nova Science Publishers , 2009, 1, Chapter 3, 1-31 p.Chapter in book (Refereed)
Abstract [en]

Flavonoids, carotenoids and tocopherols are antioxidants with alleged positive effect on the cardiovascular system. To investigate other possible pharmacological mechanisms, we examined common substances from these groups and others derived from the same biosynthesis pathway concerning their effect on angiotensin-converting enzyme (ACE) activity in human endothelial cells.

Cultered human endothelial cells from umbilical veins (HUVEC) were used and incubated for 10 minutes with flavonoids, terpenes, sterols and precursor molecules. The flavonoids tested were the isoflavone genistein, the flavonol quercetin, the epi-flavan-3-ols epicatechin, epicatechingallate, epigallocatechin, epigallocatechingallate, procyanidin and the biflavan sciadopitysin. The terpenoids tested were the diterpenes α-tocopherol and ginkgolides A, B, C, the sesquiterpene bilobalide, the triterpenes ginsenoside Rb1, Rb2, Rc, Rd, Re, Rf, Rg1 and the tetraterpene β-carotene. The sterols tested were stigmasterol, lanosterol and cholesterol. The biosynthesis precursor molecules tested were mevalonic acid, malonic acid, shikimic acid, chorismic acid and the progenitor squalene. 

 

 

 

Place, publisher, year, edition, pages
Nova Science Publishers , 2009, 1, Chapter 3. 1-31 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-21480ISBN: 978-1-60692-619-2 (print)OAI: oai:DiVA.org:liu-21480DiVA: diva2:241736
Available from: 2009-10-05 Created: 2009-10-02 Last updated: 2013-05-02Bibliographically approved

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Persson, IngridPersson, Karin

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