Accumulation of silver and delayed wound healing inhuman skin: an ex vivo study of different silverdressings
2009 (English)In: Wounds (King of Prussia, Pa.), ISSN 1044-7946Article in journal (Other academic) Submitted
Silver is commonly used in wound dressings and topical formulations to assist in themanagement of wounds that are infected or at risk of becoming infected. They providepotent broad-spectrum antimicrobial activity, but should cause no sustained staining ofthe skin, dermal or systemic accumulation of silver, or discomfort to the patient.However, clinicians and health care personnel have been worried about topical stainingof the skin, and complaints of additional pain from patients treated with some silverdressings. Some delay in wound healing has also been noticed and reported. The reasons for this are not clear and we thought that further studies about possible accumulation ofsilver and silver dressings on wound healing were required. We studied possible silveraccumulation and wound healing in human dermal skin. Our results showed that most ofthe dressings or treatments discoloured the wound surface and there was a dermalaccumulation of what we assume to be silver particles. We found different grades ofaccumulation in deep dermal tissue, particularly around blood vessels, depending on thedressing used. The results also indicated that all products tested delayed wound healing.
Place, publisher, year, edition, pages
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-21901OAI: oai:DiVA.org:liu-21901DiVA: diva2:241970