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Lyme borreliosis in Sweden - Diagnostic performance of five commercial Borrelia serology kits using sera from well-defined patient groups
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Clinical Immunology.ORCID iD: 0000-0002-3993-9985
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Clinical Immunology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Immunology and Transfusion Medicine.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Infectious Diseases. Östergötlands Läns Landsting, Centre for Medicine, Department of Infectious Diseases in Östergötland.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Clinical Microbiology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Microbiology.
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2004 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 112, no 1, 74-78 p.Article in journal (Refereed) Published
Abstract [en]

Five commercial Borrelia serology kits available in Sweden were evaluated and compared for their diagnostic performance in sera from clinically well-characterized patient groups. With the clinically defined groups as the gold standard, i.e. without knowledge of antibody status in serum and cerebrospinal fluid, the diagnostic performance of the kits was compared and important differences in diagnostic usefulness were found. The kits from Abbot and DAKO, that often predict clinically relevant Borrelia infection and do not detect antibodies in sera from patients without strong suspicion of Borrelia infection, were considered the most useful in the population studied. This kind of validation study is an important part of good laboratory practice and should be performed by laboratories serving patient populations with varying endemicity of Borrelia.

Place, publisher, year, edition, pages
2004. Vol. 112, no 1, 74-78 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-22036DOI: 10.1111/j.1600-0463.2004.apm1120112.xLocal ID: 1087OAI: oai:DiVA.org:liu-22036DiVA: diva2:242338
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13

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Ekerfelt, ChristinaErnerudh, JanForsberg, PiaJönsson, Anna-LenaVrethem, MagnusForsum, Urban

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Ekerfelt, ChristinaErnerudh, JanForsberg, PiaJönsson, Anna-LenaVrethem, MagnusForsum, Urban
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Faculty of Health SciencesClinical ImmunologyDepartment of Clinical Immunology and Transfusion MedicineInfectious DiseasesDepartment of Infectious Diseases in ÖstergötlandClinical MicrobiologyDepartment of Clinical MicrobiologyDepartment of Neuroscience and LocomotionDepartment of Neurology
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Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)
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