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Temporary preservation of β-cell function by diazoxide treatment in childhood type 1 diabetes
Astrid Lindgrens Barnsjukhus Stockholm.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
Barnkliniken Universitetssjukhuset, Örebro.
Barnkliniken Ryhovs sjukhus, Jönköping.
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2004 (English)In: Diabetes Care, ISSN 0149-5992, Vol. 27, no 9, 2191-2197 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE - We examined the effect of diazoxide, an ATP-sensitive K + channel opener and inhibitor of insulin secretion, on β-cell function and remission in children at clinical onset of type 1 diabetes. RESEARCH DESIGN AND METHODS - A total of 56 subjects (21 girls and 35 boys, age 7-17 years) were randomized to 3 months of active treatment (diazoxide 5-7.5 mg/kg in divided doses) or placebo in addition to multiple daily insulin injections and were followed for 2 years. RESULTS - Diazoxide decreased circulating C-peptide concentrations by ∼50%. After cessation of the treatment, basal and meal-stimulated C-peptide concentrations increased to a maximum at 6 months, followed by a decline. Meal-stimulated C-peptide concentration was significantly higher at 12 months (0.43 ± 0.22 vs. 0.31 ± 0.26 nmol/l, P = 0.018) and tended to fall less from clinical onset to 24 months in the diazoxide- vs. Placebo-treated patients (-0.05 ± 0.24 vs. -0.18 ± 0.26 nmol/l, P = 0.064). At 24 months, the meal-stimulated C-peptide concentrations were 0.24 ± 0.20 and 0.20 ± 0.17 nmol/l, respectively. Side effects of diazoxide were prevalent. CONCLUSIONS - This study demonstrates that partial inhibition of insulin secretion for 3 months at onset of childhood type 1 diabetes suspends the period of remission and temporarily preserves residual insulin production. Further evaluation of the full potential of β-cell rest will require compounds with less side effects as well as protocols optimized for sustained secretory arrest.

Place, publisher, year, edition, pages
2004. Vol. 27, no 9, 2191-2197 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-22077Local ID: 1157OAI: diva2:242390
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

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