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Optical methods for tympanic membrane colour and shape assessment
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology.
2004 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

Otitis media is one of the most common diseases of childhood. Increasing antibiotic resistance has lead to awareness of the importance of the diagnostic accuracy in otitis media. The recommended treatment of acute otitis media (AOM) involves antibiotics whereas in otitis media with effusion (OME) it does not. Hence, there is a need for new technology that can help separating between the two (and healthy conditions). The work in this thesis suggests a combination of diffuse reflectance spectroscopy and a new technique for surface-curvature measurement as a tool for assisted diagnosis in otitis media.

Diffuse reflectance spectroscopy was applied to estimate the degree of tympanic membrane erythema by means of two erythema detection algorithms from the literature. Measurements were performed in children with otitis media with effusion (15 ears) and in a healthy reference group (15 ears). The children with OME were scheduled for tympanostomy tube placement, which involves perforation of the tympanic membrane. Spectroscopic recordings were performed before and after perforation of the tympanic membrane in the OME group and once in the healthy reference group. Significant differences between the erythema estimates were present between the groups (p < 0.05).

A new surface-curvature measurement system, consisting of two parallel optical fibre arrays, was designed and tested using convex and concave polyacetal plastic (delrin) objects. By sequentially illuminating the surface and detecting the backscattered light intensity, a source-detector intensity matrix was formed. A simplified mathematical model for light scattering showed similar shape and amplitude of the source-detector matrices as did the experimental results. The surface-curvature measurement system distinguishes correctly between convex and concave surfaces.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet , 2004. , 45 p.
Series
Linköping Studies in Science and Technology. Thesis, ISSN 0280-7971 ; 1098
Series
LiU-TEK-LIC, 27
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-22164Local ID: 1283ISBN: 91-7373-973-1 (print)OAI: oai:DiVA.org:liu-22164DiVA: diva2:242477
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2013-11-13
List of papers
1. Fibre-optic array for curvature assessment: application in otitis diagnosis
Open this publication in new window or tab >>Fibre-optic array for curvature assessment: application in otitis diagnosis
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2004 (English)In: Medical & Biological Engineering & Computing, ISSN 0140-0118, Vol. 42, no 2, 245-252 p.Article in journal (Refereed) Published
Abstract [en]

A contact-free sensor consisting of two parallel optical-fibre arrays was designed to assess surface shapes of diffusely scattering media. By sequentially illuminating objects using one fibre array and detecting the diffusely back-scattered photons by the other, a source-detector intensity matrix was formed, where the matrix element (i, j) was the intensity at detector j when light source i was excited. Experimental data from convex and concave polyacetal plastic surfaces were recorded. A mathematical model was used for simulating source-detector intensity matrices for the surfaces analysed in the experiments. Experimental results from the system were compared with the theoretically expected results provided by the mathematical model. The shape and relative amplitude showed similar behaviour in the experiments and simulations. A convex/concave discriminator index D, representing the detected intensity difference between two source-detector separations, was defined. The relative dynamic range of D, defined as the difference between the maximum and the minimum divided by the mean of the index, was 1.37 for convex surfaces and 0.68 for concave surfaces, at a measuring distance of 4.5mm. The index D was positive for convex surfaces and negative for concave surfaces, which showed that the system could distinguish between convex and concave surfaces, an important result for the diagnosis of otitis media.

Keyword
Diffuse reflection, Optical imaging, Otitis media, Surface shape identification
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:liu:diva-13008 (URN)10.1007/BF02344638 (DOI)
Available from: 2008-03-20 Created: 2008-03-20 Last updated: 2014-10-08
2. Diffuse reflectance spectroscopy of the human tympanic membrane in otitis media
Open this publication in new window or tab >>Diffuse reflectance spectroscopy of the human tympanic membrane in otitis media
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2004 (English)In: Physiological Measurement, ISSN 0967-3334, Vol. 25, no 6, 1473-1483 p.Article in journal (Refereed) Published
Abstract [en]

We have investigated if features in the diffuse reflectance spectra from in vivo spectroscopic measurements of the tympanic membrane could aid the diagnosis of otitis media in children. Diffuse reflectance spectroscopy, in the visible wavelength range, was used in 15 ears from children with otitis media with effusion before and after myringotomy and in 15 healthy ears as a reference. Two previously published erythema detection algorithms yielded numerical quantities of haemoglobin content. With a combination of the algorithms, induced erythema (after myringotomy) was distinguished from healthy ears using Student's t-test (p < 0.01). Otitis media with mucous effusion was distinguished from (1) otitis media with serous effusion, (2) induced erythema and (3) healthy ears, (p < 0.05) using Student's t-test for independent groups and the paired t-test for dependent groups. Our results imply that reflectance spectroscopy is a promising technique to be used for the diagnosis of otitis media.

Keyword
diffuse reflectance spectroscopy, otitis media, tympanic membrane, erythema
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:liu:diva-13009 (URN)10.1088/0967-3334/25/6/012 (DOI)
Available from: 2008-03-20 Created: 2008-03-20 Last updated: 2013-11-13

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Sundberg, Mikael

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