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FLT3 ligand regulates apoptosis through AKT-dependent inactivation of transcription factor FoxO3
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of cell biology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of cell biology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of cell biology.
2004 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 318, no 4, 899-903 p.Article in journal (Refereed) Published
Abstract [en]

Proliferation, differentiation, and survival of hematopoietic cells are regulated by cytokines, acting through specific receptors. FLT3 ligand (FL) is one of the most important cytokines for regulation of the hematopoietic system, and its receptor FLT3 is expressed on both stem cells and progenitors. Regulation of Forkhead transcription factors has been described as an important mechanism to control apoptosis and cell cycle progression in hematopoietic progenitors. Here we report that FL induces AKT/PKB activation, which in turn phosphorylates and thereby inactivates the Forkhead protein FoxO3 in the progenitor cell line FDC-P1 stably expressing murine FLT3 receptor. Phosphorylation of AKT and FoxO3 was blocked by the PI-3 kinase inhibitor LY294002 but not by the MAP kinase inhibitor PD98059. Expression of a mutated FoxO3, in which all three inhibitory phosphorylation sites were mutated to alanine, led to rapid increase of apoptotic cells in the presence of FL. These results suggest that FL-induced regulation of apoptosis is executed by FoxO3.

Place, publisher, year, edition, pages
2004. Vol. 318, no 4, 899-903 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-22314DOI: 10.1016/j.bbrc.2004.04.110Local ID: 1508OAI: oai:DiVA.org:liu-22314DiVA: diva2:242627
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13

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Jönsson, MariaEngström, MariaJönsson, Jan-Ingvar

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