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A fourfold difference in the incidence of type 1 diabetes between Sweden and Lithuania but similar prevalence of autoimmunity
Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Linköping University, Faculty of Health Sciences.
Laboratory of Paediatric Endocrinology, Kaunas University of Medicine, Kaunas, Lithuania.
Laboratory of Paediatric Endocrinology, Kaunas University of Medicine, Kaunas, Lithuania.
Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Linköping University, Faculty of Health Sciences.
2004 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 66, no 2, 173-181 p.Article in journal (Refereed) Published
Abstract [en]

We investigated whether other autoimmune disorders in addition to type 1 diabetes are more common in Sweden than Lithuania, and if there are any differences in inheritance patterns of both type 1 diabetes and other autoimmune disorders.

Data from 517 children in southeast Sweden and 286 children in Lithuania aged 0–15 years were included in the study. Age- and sex-matched control children were randomly selected. Information was collected by questionnaire.

Of the children with diabetes in Sweden, 13.2% had a family member with type 1 diabetes compared to 7% of children with diabetes in Lithuania (P<0.01) (OR=2.01). No such difference was seen for other autoimmune diseases in family members of children with diabetes (Sweden 12%, Lithuania 14%, n.s.). Control children in Lithuania had family members with autoimmunity more frequently (15.3%) than control children in Sweden (7.4%, P<0.001) (OR=2.26). This difference was most pronounced in mothers. The Lithuanian control children had an autoimmune disease more frequently than the controls in Sweden (4.7% versus 1.5%, respectively, P<0.001) (OR=3.21).

There seem to be environmental factors that specifically contribute to the development of type 1 diabetes, factors which are less related to the development of autoimmunity in general.

Place, publisher, year, edition, pages
2004. Vol. 66, no 2, 173-181 p.
Keyword [en]
type 1 diabetes, autoimmune disorders, environmental factors, inheritance factors
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-22337DOI: 10.1016/j.diabres.2004.03.001Local ID: 1538OAI: oai:DiVA.org:liu-22337DiVA: diva2:242650
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13Bibliographically approved

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Samuelsson, UlfSaduaskaite-Kühne, VaivaLudvigsson, Johnny

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