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Mammary epithelial paracellular permeability in atopic and non-atopic mothers versus childhood atopy
Dept of Epidemiology Köpenhamn, Danmark.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics.
Dept of Epidemiology Köpenhamn, Danmark.
Centre of International Child Health London, UK.
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2004 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, Vol. 15, no 2, 123-126 p.Article in journal (Refereed) Published
Abstract [en]

Sodium/potassium (Na/K) ratios are considered to be a marker of mammary epithelial paracellular permeability. The aim of the present study was to investigate the association between maternal atopy and Na/K ratios in breast milk and the association between Na/K ratios in breast milk and the development of atopy in the offspring. Early and mature milk samples were obtained from 30 atopic and 43 non-atopic women. We found no differences in the Na/K ratios between atopic and non-atopic women. At 18 months of age, 22 (30%) of the children had a positive skin prick test (SPT) and 26 (36%) had symptoms of atopic diseases. Overall, high levels of Na/K compared with low and slightly raised levels of Na/K in the maternal milk tended to be associated with a positive SPT and atopic disease. However, if the mother was atopic, high levels of Na/K in early or mature milk were associated with a significantly increased risk of a positive SPT or atopic disease in the offspring [RR = 4.8 (1.9-12)] whereas no such association was observed in non-atopic mothers [RR = 0.8 (0.4-1.7), p for interaction = 0.001]. Thus, high Na/K levels in the breast milk may be associated with the development of atopy and atopic diseases in the offspring of atopic mothers.

Place, publisher, year, edition, pages
2004. Vol. 15, no 2, 123-126 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-22342DOI: 10.1046/j.1399-3038.2003.00138.xLocal ID: 1543OAI: diva2:242655
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

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Fagerås Böttcher, MalinDuchén, Karel
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Faculty of Health SciencesPediatricsDepartment of Paediatrics in Linköping
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Pediatric Allergy and Immunology
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