Parecoxib impairs early tendon repair but improves later remodeling
2004 (English)In: American Journal of Sports Medicine, ISSN 0363-5465, Vol. 32, no 7, 1743-1747 p.Article in journal (Refereed) Published
Background: Cyclooxygenase-2 inhibitors inhibit bone repair. Hypothesis: Cyclooxygenase inhibitors might also have a negative effect on early tendon repair, although a positive effect on late tendon repair previously has been shown. Study Design: Controlled laboratory study. Methods: Achilles tendon transection was performed on 80 rats. Sixty rats were given daily intramuscular injections of either parecoxib (6.4 mg/kg body weight) or saline for the first 5 days after surgery and sacrificed either at 8 or 14 days. The remaining 20 rats were given intramuscular parecoxib or saline injections from day 6 until sacrifice at 14 days. Results: At 8 days, early parecoxib treatment caused a 27% decrease in force at failure (P = .007), a 25% decrease in maximum stress (P = .01), and a 31 % decrease in energy uptake (P = .05). Stiffness and transverse area were not significantly affected. At 14 days, early parecoxib treatment caused a decrease in stiffness (P = .004). In contrast to early treatment, late parecoxib treatment caused a 16% decrease in cross-sectional area (P = .03) and a 29% increase in maximum stress (P = .04). Conclusions: During early tendon repair, a cyclooxygenase-2 inhibitor had a detrimental effect. During remodelling, however, inflammation appears to have a negative influence, and cyclooxygenase-2 inhibitors might be of value. Clinical Relevance: The results suggest that cyclooxygenase-2 inhibitors should be used with care in the early period after tendon injury.
Place, publisher, year, edition, pages
2004. Vol. 32, no 7, 1743-1747 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-22676DOI: 10.1177/0363546504263403Local ID: 1966OAI: oai:DiVA.org:liu-22676DiVA: diva2:242989