liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Increased urinary excretion of 8-hydroxydeoxyquanosine in engine room personnel exposed to polycyclic aromatic hydrocarbons
Show others and affiliations
2004 (English)In: Occupational and Environmental Medicine, ISSN 1351-0711, Vol. 61, no 8, 692-696 p.Article in journal (Refereed) Published
Abstract [en]

Background: Previous investigations indicate that engine room personnel on ships are exposed to polycyclic aromatic hydrocarbons (PAH) from oil and oil products, with dermal uptake as the major route of exposure. Several PAH are known carcinogens and mutagens. Aims: To investigate the urinary excretion of a marker for oxidative DNA damage, 8-hydroxydeoxyguanosine (8OHdG), in engine room personnel, and to study the association between 8OHdG and 1-hydroxypyrene (1OHP), a biological marker for PAH exposure. Methods: Urine samples were collected from engine room personnel (n = 36) on 10 Swedish and Norwegian ships and from unexposed controls (n = 34) with similar age and smoking habits. The exposure to oils, engine exhaust, and tobacco smoke 24 hours prior to sampling was estimated from questionnaires. The urinary samples were frozen for later analyses of 8OHdG and 1OHP by high performance liquid chromatography. Results: Excretion in urine of 8OHdG (adjusted to density 1.022) was similar for controls (mean 18.0 nmol/l, n = 33), and for those who had been in the engine room without skin contact with oils (mean 18.7 nmol/l, n = 15). Engine room personnel who reported skin contact with oil had increased excretion of 8OHdG (mean 23.2 nmol/l, n = 19). The difference between this group and the unexposed controls was significant. The urinary levels of ln 1OHP and ln 8OHdG were significantly correlated, and the association was still highly significant when the effects of smoking and age were accounted for in a multiple regression analysis. Conclusion: Results indicate that exposure to PAH or possibly other compounds from skin contact with oils in engine rooms may cause oxidative DNA damage.

Place, publisher, year, edition, pages
2004. Vol. 61, no 8, 692-696 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-22711DOI: 10.1136/oem.2003.007435Local ID: 2008OAI: diva2:243024
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Tagesson, Christer
By organisation
Faculty of Health SciencesOccupational and Environmental MedicineOccupational and Environmental Medicine Centre
In the same journal
Occupational and Environmental Medicine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 30 hits
ReferencesLink to record
Permanent link

Direct link