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Fewer melanocytic nevi found in children with active atopic dermatitis than in children without dermatitis
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of dermatology and venereology. Östergötlands Läns Landsting, Centre for Medicine, Department of Dermatology and Venerology in Östergötland.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Occupational and Environmental Medicine.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of dermatology and venereology. Östergötlands Läns Landsting, Centre for Medicine, Department of Dermatology and Venerology in Östergötland.
2004 (English)In: Archives of Dermatology, ISSN 0003-987X, Vol. 140, no 12, 1471-1475 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate the effects of atopic diseases on nevus development during childhood. Design: A descriptive survey of nevi in a cohort of 8- and 9-year-old children combining a skin examination and a validated questionnaire regarding atopic dermatitis, allergic rhinoconjunctivitis, and bronchial asthma. Setting: Fifty-one primary schools in Sweden. Participants: A total of 788 children born in 1992 participated in 1999 in a prevalence study of allergic diseases. The present study was restricted to the 545 children from that study who were still living in the community, and 515 (94%) of them participated. The cumulative incidence of atopic dermatitis, allergic rhino-conjunctivitis, and bronchial asthma was 24%, 12%, and 13%, respectively, from birth to age 7 years as reported by questionnaire, 3% reported all 3 diagnoses. Results: Children with reported atopic dermatitis and findings of active dermatitis on examination had fewer nevi (median, 4, mean, 7.4) than children with no reported atopic disease and no active dermatitis found on examination (median, 9, mean, 11.2) (P<.001). Children who developed active atopic dermatitis after the questionnaire was filled out (ie, during the last 2 years) had fewer nevi than children with no atopic disease (median, 3, mean, 5.3) (P<.001). There was no difference in nevus number between the children with bronchial asthma or allergic rhinoconjunctivitis and children with no atopic disease. Conclusion: Children with atopic dermatitis had few melanocytic nevi, which suggests that the proinflammatory cytokine network in the atopic skin might inhibit melanocyte growth and/or progression to nevi.

Place, publisher, year, edition, pages
2004. Vol. 140, no 12, 1471-1475 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-22978DOI: 10.1001/archderm.140.12.1471Local ID: 2350OAI: oai:DiVA.org:liu-22978DiVA: diva2:243291
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13

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Synnerstad, IngridNilsson, LennartFredrikson, MatsRosdahl, Inger

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Faculty of Health SciencesDivision of dermatology and venereologyDepartment of Dermatology and Venerology in ÖstergötlandPediatricsDepartment of Paediatrics in LinköpingOccupational and Environmental Medicine
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