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Lysosomal redox-active iron is important for oxidative stress-induced DNA damage
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Pathology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.
2004 (English)In: Annals of the New York Academy of Sciences, ISSN 0077-8923, Vol. 1019, 285-288 p.Article in journal (Refereed) Published
Abstract [en]

Data show that specifically chelating lysosomal redox-active iron can prevent most H2O2-induced DNA damage. Lysosomes seem to contain the major pool of redox-active labile iron within the cell. Under oxidative stress conditions, this iron may then relocate to the nucleus and play an important role for DNA damage by taking part in Fenton reactions.

Place, publisher, year, edition, pages
2004. Vol. 1019, 285-288 p.
Keyword [en]
lysosomes, oxidative stress, desferrioxamine, telomeres
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-23465DOI: 10.1196/annals.1297.048Local ID: 2920OAI: oai:DiVA.org:liu-23465DiVA: diva2:243779
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2009-10-15

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Kurz, TinoBrunk, Ulf

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