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Local production of nitric oxide in patients with tuberculosis
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.
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2004 (English)In: The International Journal of Tuberculosis and Lung Disease, ISSN 1027-3719, Vol. 8, no 9, 1134-1137 p.Article in journal (Refereed) Published
Abstract [en]

Nitric oxide (NO), produced by the inducible nitric oxide synthase (iNOS), is important in host defence against Mycobacterium tuberculosis in rodents, but the presence of high-output NO production in human tuberculosis has been controversial. We investigated iNOS and nitrotyrosine (Ntyr) expression in pleural (n = 7), pulmonary (n = 5) and lymph node biopsies (n = 5) from untreated, newly diagnosed tuberculosis patients. Many iNOS and Ntyr reactive macrophages were observed in granulomas, including Langhans giant cells, indicating high-output NO production at the primary site of disease in tuberculosis.

Place, publisher, year, edition, pages
2004. Vol. 8, no 9, 1134-1137 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-23559Local ID: 3038OAI: diva2:243873
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

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Schön, ThomasSundqvist, Tommy
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