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Contribution of electron and confocal microscopy in the study of Leishmania-macrophage interactions
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.
Canada.
2004 (English)In: Microscopy and Microanalysis, ISSN 1431-9276, Vol. 10, no 5, 656-661 p.Article in journal (Refereed) Published
Abstract [en]

Promastigotes of the protozoan parasite genus Leishmania are inoculated into a mammalian host when an infected sand fly takes a bloodmeal. Following their opsonization by complement, promastigotes are phagocytosed by macrophages. There, promastigotes differentiate into amastigotes, the form of the parasite that replicates in the phagolysosomal compartments of host macrophages. Although the mechanisms by which promastigotes survive the microbicidal consequence of phagocytosis remain, for the most part, to be elucidated, evidence indicates that glycoconjugates play a role in this process. One such glycoconjugate is lipophosphoglycan, an abundant promastigote surface glycolipid. Using quantitative electron and confocal laser scanning microscopy approaches, evidence was provided that L. donovani promastigotes inhibit phagolysosome biogenesis in a lipophosphoglycan-dependent manner. This inhibition correlates with an accumulation of periphagosomal F-actin, which may potentially form a physical barrier that prevents L. donovani promastigote-containing phagosomes from interacting with endocytic vacuoles. Inhibition of phagosome maturation may constitute a strategy to provide an environment propitious to the promastigote-to-amastigote differentiation.

Place, publisher, year, edition, pages
2004. Vol. 10, no 5, 656-661 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-23684DOI: 10.1017/S1431927604040851Local ID: 3182OAI: oai:DiVA.org:liu-23684DiVA: diva2:243999
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

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Rasmusson, Birgitta

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