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Expression of p27 and MAPK proteins involved in all-trans retinoic acid-induced apoptosis and cell cycle arrest in matched primary and metastatic melanoma cells.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of dermatology and venereology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of dermatology and venereology. Östergötlands Läns Landsting, Centre for Medicine, Department of Dermatology and Venerology in Östergötland.
2004 (English)In: International Journal of Oncology, ISSN 1019-6439, Vol. 25, no 5, 1241-1248 p.Article in journal (Refereed) Published
Abstract [en]

We investigated whether p27 and mitogen-activated protein kinase (MAPK) proteins were involved in all-trans retinoic acid (atRA)-induced apoptosis and cell cycle arrest. Matched primary and metastatic melanoma cells were exposed to atRA. Apoptosis and cell cycle were detected by flow cytometry. Expression of p27, Ras, B-raf, Mek and Erk proteins was examined. Results showed that atRA induced apoptosis and cell cycle arrest in both primary and metastatic melanoma cells. The primary melanoma cells were more vulnerable than their matched metastatic cells. Expression of p27 was increased, while MAPK proteins were decreased, this response was dose- and time-dependent. Alterations of these proteins were more pronounced in primary melanoma cells than in the matched metastases. These data indicate that up-regulation of p27 and down-regulation of MAPK proteins were involved in atRA-induced apoptosis and cell cycle arrest in melanoma.

Place, publisher, year, edition, pages
2004. Vol. 25, no 5, 1241-1248 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-23731Local ID: 3238OAI: oai:DiVA.org:liu-23731DiVA: diva2:244046
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13

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Zhang, HongRosdahl, Inger

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Zhang, HongRosdahl, Inger
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Faculty of Health SciencesDivision of dermatology and venereologyDepartment of Dermatology and Venerology in Östergötland
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International Journal of Oncology
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CiteExportLink to record
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