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Efficacy of venlafaxine ER in patients with social anxiety disorder: A double-blind, placebo-controlled, parallel-group comparison with paroxetine
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2004 (English)In: Human Psychopharmacology: Clinical and Experimental, ISSN 0885-6222, Vol. 19, no 6, 387-396 p.Article in journal (Refereed) Published
Abstract [en]

This study evaluated the anxiolytic efficacy, safety and tolerability of a flexible dose of venlafaxine extended release (ER) compared with placebo and paroxetine in the short-term treatment of generalized social anxiety disorder (SAD). Adult outpatients with generalized SAD (n=434) were randomized to receive capsules of venlafaxine ER 75 mg to 225 mg/day, paroxetine 20 mg to 50 mg/day, or placebo for 12 weeks. The primary efficacy variable was the Liebowitz social anxiety scale total score. Secondary efficacy variables included the patient-rated social phobia inventory and the proportion of responders in each group (a responder was defined as having a clinical global impression-improvement score of 1 or 2). Treatment with venlafaxine ER was associated with significantly greater improvement than treatment with placebo for all primary and secondary efficacy variables (p<0.05). No significant differences in primary or secondary efficacy variables were observed between the venlafaxine ER and paroxetine groups. The week 12 response rates were 69%, 66% and 36% for the venlafaxine ER, paroxetine and placebo groups, respectively. Both active treatments were generally well tolerated and were associated with a similar incidence of adverse events. This study shows that venlafaxine ER is an effective, safe and well-tolerated drug treatment for SAD.

Place, publisher, year, edition, pages
2004. Vol. 19, no 6, 387-396 p.
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Medical and Health Sciences
URN: urn:nbn:se:liu:diva-23912DOI: 10.1002/hup.602Local ID: 3459OAI: diva2:244227
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

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Sjödin, Ingemar
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Faculty of Health SciencesPsychiatryDepartment of Psychiatry
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