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mRNA and protein expression of PUMA in sporadic colorectal cancer.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of surgery. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
2004 (English)In: Oncology Reports, ISSN 1021-335X, Vol. 12, no 6, 1245-1249 p.Article in journal (Refereed) Published
Abstract [en]

PUMA is a BH3-only member of the Bcl-2 family, up-regulated by p53 as a response to DNA damage. We have investigated the mRNA expression of PUMA with real-time PCR in 94 colorectal adenocarcinomas and the corresponding normal mucosa. Among them PUMA protein expression was investigated with immunohistochemistry in 23 tumours and 17 corresponding normal mucosa samples. The mRNA expression of PUMA decreased in 4% and increased in 4% of the tumours compared with the normal mucosa. The protein expression of PUMA decreased in 6% and increased in 29% of the tumours compared with the normal mucosa. Decreased PUMA expression in the tumour compared with the corresponding mucosa was correlated with the distal colon and rectum (P=0.02). We did not find any other relationship to clinical or pathological features. We suggest that the changes in PUMA expression may be of minor importance in the development of colorectal cancer.

Place, publisher, year, edition, pages
2004. Vol. 12, no 6, 1245-1249 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-23966Local ID: 3516OAI: oai:DiVA.org:liu-23966DiVA: diva2:244282
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

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Jansson, AgnetaArbman, GunnarSun, Xiao-Feng

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Faculty of Health SciencesOncologyDivision of surgeryDepartment of Surgery in ÖstergötlandDepartment of Oncology UHL
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