Modulation of neuronal glutamate transporter rEAAC1 mRNA expression in rat brain by amitriptyline
2004 (English)In: Brain Research. Molecular Brain Research, ISSN 0169-328X, E-ISSN 1872-6941, Vol. 126, no 1, 74-77 p.Article in journal (Refereed) Published
Glutamate transporters regulate the glutamate concentration in the synaptic cleft within the CNS, a regulation required for normal brain function. In several neurological conditions, the amount of glutamate is altered. One reason for the changes in glutamate concentration might be impaired glutamate transporter function. In this study, an in situ hybridisation technique has been used to elucidate changes in mRNA expression of the glutamate transporter, excitatory amino acid carrier 1 (EAAC1), after treatment with the tricyclic antidepressant (TCA) amitriptyline. The results lead to the suggestion that treatment with tricyclic antidepressants leads to changes in the EAAC1 mRNA expression in rat brain suggesting involvement of the glutamate system in the tricyclic treatment of depression.
Place, publisher, year, edition, pages
2004. Vol. 126, no 1, 74-77 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-24088DOI: 10.1016/j.molbrainres.2004.03.023ISI: 000222569100009Local ID: 3654OAI: oai:DiVA.org:liu-24088DiVA: diva2:244405