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Can natriuretic peptides be used for the diagnosis of diastolic heart failure?
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Cardiology. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.ORCID iD: 0000-0001-6353-8041
2004 (English)In: European Journal of Heart Failure, ISSN 1388-9842, Vol. 6, no 3, 281-287 p.Article in journal (Refereed) Published
Abstract [en]

Many patients with heart failure have stiff hearts with an increased wall thickness and small volumes leading to diastolic dysfunction. Different definitions for diastolic heart failure have been proposed but today there is no generally accepted definition and there are few large controlled studies telling us how it should be managed. Natriuretic peptides (BNP or NT-proBNP) might be used to detect patients with diastolic dysfunction especially in those patients having a restrictive filling pattern or pseudo-normalised mitral flow pattern and in those, who are symptomatic. However, patients with relaxation abnormalities and mild symptoms or asymptomatic may have normal levels of the natriuretic peptides indicating no or only slight elevation of the left ventricular filling pressures. Thus low levels cannot be used as a rule out diagnosis of diastolic dysfunction.

Place, publisher, year, edition, pages
2004. Vol. 6, no 3, 281-287 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-24312DOI: 10.1016/j.ejheart.2004.01.005Local ID: 3935OAI: diva2:244630
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2013-09-26

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Dahlström, Ulf
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