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Prognostic factors in patients with carcinoma in situ treated with intravesical bacille Calmette-Guérin
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Division of surgery. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Urology in Östergötland.
2004 (English)In: Scandinavian Journal of Urology and Nephrology, ISSN 0036-5599, Vol. 38, no 4, 285-290 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To report prognostic factors and follow-up data for an unselected group of patients with carcinoma in situ (CIS) of the urinary bladder treated with bacille Calmette-Guérin (BCG). Material and Methods: The clinical records of patients with CIS treated with BCG were reviewed. All 173 patients treated between 1986 and 1997 in four hospitals in two Swedish cities were included. The median follow-up period was 72 months (range 6-154 months). The impact of 18 variables on the times to recurrence and progression was studied using multivariate Cox proportional hazard regression and Kaplan-Meier analyses. Results: No pre-treatment variables, including type of CIS and T1G3 tumour, had prognostic value in terms of time to progression. The result of the first cystoscopy had a very strong prognostic importance: 44% of patients with a positive first cystoscopy progressed in stage, 59% were BCG failures and 35% died from urothelial cancer. The corresponding values for patients with a negative first cystoscopy were 11%, 18% and 8%. Fourteen patients (8%) were diagnosed with an upper urinary tract tumour but no variable had prognostic significance. The diagnoses of the upper urinary tract tumours were evenly distributed during follow-up. Conclusions: We were not able to predict which patients would respond favourably to BCG. Cystectomy should be strongly considered even after a positive first cystoscopy. The accumulated incidence of patients with bladder CIS and a subsequent upper urinary tract tumour is rather high but it is questionable whether the prognosis will improve if routine follow-up urographies are performed.

Place, publisher, year, edition, pages
2004. Vol. 38, no 4, 285-290 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-24313DOI: 10.1080/00365590410028692Local ID: 3936OAI: diva2:244631
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

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Damm, Ole
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Faculty of Health SciencesDivision of surgeryDepartment of Urology in Östergötland
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Scandinavian Journal of Urology and Nephrology
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