liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Concentrations of polychlorinated biphenyls in blood and the risk for testicular cancer
Show others and affiliations
2004 (English)In: International Journal of Andrology, ISSN 0105-6263, Vol. 27, no 5, 282-290 p.Article in journal (Refereed) Published
Abstract [en]

An increasing incidence of testicular cancer has been reported from several western countries during the last decades. According to current hypothesis testicular cancer is initiated during the foetal period and exposure to endocrine disruptors such as some persistent organic pollutants has been of concern. We have previously reported the results for concentrations of polychlorinated biphenyls (PCBs), p,p′-dichlorodiphenyl-dichloroethylene (pp′-DDE), hexachlorobenzene (HCB) and chlordanes in 58 cases with testicular cancer, 61 age-matched controls and 44 case mothers and 45 control mothers. In that report, significant increase of odds ratio (OR) was found for sum of PCBs, HCB, trans- and cis-nonachlordane in case mothers. These data have now been further analysed for 37 congeners of PCBs. No significant differences were found among cases and controls. However, case mothers had significantly increased concentrations of a number of PCB congeners. A priori decided grouping of PCBs yielded for oestrogenic PCBs OR = 2.4, 95% confidence interval (CI) = 0.95-6.0, enzyme-inducing PCBs OR = 2.6, 95% CI = 1.03-6.5 and toxic equivalents (TEQ) yielded OR = 3.3, 95% CI = 1.3-8.4. These data further elucidate the role of foetal exposure to different PCB congeners in the aetiology of testicular cancer.

Place, publisher, year, edition, pages
2004. Vol. 27, no 5, 282-290 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-24322DOI: 10.1111/j.1365-2605.2004.00489.xLocal ID: 3945OAI: diva2:244640
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Starkhammar, Hans
By organisation
Faculty of Health SciencesOncologyDepartment of Oncology UHL
In the same journal
International Journal of Andrology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 69 hits
ReferencesLink to record
Permanent link

Direct link