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Paroxetine influences respiration in rats: Implications for the treatment of panic disorder
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Pharmacology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pharmacology.
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2004 (English)In: European Neuropsychopharmacology, ISSN 0924-977X, Vol. 14, no 1, 29-37 p.Article in journal (Refereed) Published
Abstract [en]

Since hyperventilation and shortness of breath are characteristic features of panic attacks, and since the attacks can be elicited by CO2 inhalation, an involvement of central or peripheral chemoreceptors in the pathophysiology of panic disorder has been suggested. Prompted by clinical reports suggesting that the susceptibility to spontaneous as well as CO 2-induced anxiety and hyperventilation is attenuated by serotonin reuptake inhibitors (SRIs), we undertook the present study in order to explore the possible effect of an SRI, paroxetine, on baseline respiration and CO 2-induced hyperventilation in freely moving Wistar rats. A significant increase in baseline respiratory rate was seen both after 5 and 15 weeks of treatment with paroxetine. CO2 exposure induced a dose-dependent increase in respiratory rate, but not tidal volume, in both paroxetine-treated rats and controls, this response was reduced after 15 weeks of paroxetine treatment, but not after 5 weeks of treatment. We suggest that an influence on the regulation of respiration may be of importance for the anti-panic effect of SRIs.

Place, publisher, year, edition, pages
2004. Vol. 14, no 1, 29-37 p.
Keyword [en]
Panic disorder; CO2; Respiration; Rat; Hyperventilation; Paroxetine; Serotonin reuptake inhibitors
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-24388DOI: 10.1016/S0924-977X(03)00044-0Local ID: 6481OAI: diva2:244706
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

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Bengtsson, Finn
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Faculty of Health SciencesClinical PharmacologyDepartment of Clinical Pharmacology
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