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Diminished Th1-like response to autoantigens in children with a high risk of developing type 1 diabetes
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
2005 (English)In: Scandinavian Journal of Immunology, ISSN 0300-9475, Vol. 61, no 2, 173-179 p.Article in journal (Refereed) Published
Abstract [en]

The exact role of T-helper (Th) cells that precede the clinical manifestation of type 1 diabetes remains unclear. The aim of this investigation was to study the Th1- and Th2-like profile in children and adults with high risk of developing the disease. Peripheral blood mononuclear cells were collected from high-risk children and adults and from healthy individuals matched for age and gender. Using the sensitive enzyme-linked immunospot (ELISPOT) technique to divide Th1- from Th2-like lymphocytes, secretion of interferon-γ (IFN-γ) and interleukin-4 was analysed from lymphocytes spontaneously and after in vitro stimulation with different antigens, based on present paradigms regarding the pathogenesis of type 1 diabetes. Compared to the response observed in healthy individuals, we found that individuals with a high risk of developing type 1 diabetes, especially children, responded with less IFN-γ secretion to the three autoantigens glutamic acid decarboxylase 65 (GAD 65), insulin and tyrosinphosphatase (IA-2). Thus, a diminished Th1-like response by in vitro autoantigen stimulation was observed in especially children with a high risk of developing type 1 diabetes. Reduced Th1/Th2 response was related to signs of β cell exhaustion.

Place, publisher, year, edition, pages
2005. Vol. 61, no 2, 173-179 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-24402DOI: 10.1111/j.0300-9475.2005.01544.xLocal ID: 6499OAI: oai:DiVA.org:liu-24402DiVA: diva2:244720
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

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Faresjö, MariaLudvigsson, Johnny

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