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Two years of adjuvant tamoxifen in premenopausal patients with breast cancer: a randomised, controlled trial with long-term follow-up
Department of Surgery, Helsingborgs Lasarett, Helsingborg, Sweden and Department of Laboratory Medicine, div of Pathology, University Hospital, Malmö.
Department of Surgery, Helsingborgs Lasarett, Helsingborg, Sweden.
Department of Pathology, Helsingborgs Lasarett, Helsingborg.
Linköping University, Department of Biomedicine and Surgery, Oncology. Linköping University, Faculty of Health Sciences.
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2005 (English)In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 41, no 2, 256-264 p.Article in journal (Refereed) Published
Abstract [en]

Adjuvant tamoxifen treatment increases recurrence-free survival (RFS) and overall survival (OS) in early breast cancer, although in premenopausal patients the number of studies comparing tamoxifen vs no treatment are limited. We report herein the effect on RFS of adjuvant tamoxifen treatment in a multicentre trial of premenopausal patients with stage II breast cancer patients randomised between 1986 and 1991 to 2 years of tamoxifen treatment (n = 276) or no treatment (n = 288). The receptor status of the tumour was known for 541 (96%) of the patients included. Tamoxifen treatment significantly increased RFS in patients with hormone receptor-positive (oestrogen receptor-positive (ER+) and/or progesterone receptor-positive (PR+)) tumours (Relative Risk (RR) 0.65; 95% Confidence Interval (CI): 0.48–0.89, P = 0.006), and the beneficial effect of tamoxifen was extended to patients with indicators of poor prognosis, such as young age and nodal-positivity. PR status was a significant predictor of response to tamoxifen in multivariate models with testing of interactions of hormone receptor status and adjuvant therapy.

Place, publisher, year, edition, pages
2005. Vol. 41, no 2, 256-264 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-24443DOI: 10.1016/j.ejca.2004.06.030Local ID: 6551OAI: diva2:244762
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2013-01-16

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Dufmats, MonikaKällström, Ann-ChristineStål, OlleThorstenson, StenNordenskjöld, Bo
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OncologyFaculty of Health SciencesDepartment of Surgery in Östergötland
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European Journal of Cancer
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