Influence of tissue movements on laser Doppler perfusion imaging
2002 (English)In: Proceedings of SPIE Volume 4624: Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II / [ed] Alexander V. Priezzhev; Gerard L. Cote, SPIE - International Society for Optical Engineering, 2002, Vol. 4624, 106-114 p.Conference paper (Other academic)
The microvascular perfusion can be measured using laser Doppler blood flowmetry (LDF), a technique sensitive to the concentration of moving blood cells and their velocity. However, movements of the tissue itself can cause artifacts in the perfusion readings. In a clinical situation, these movement induced artifacts may arise from patient movements or from movements of internal organs e.g. the intestines or the beating heart. Therefore, we have studied how a well-controlled tissue movement affects the LDF signals during different flow conditions and for different surface structures. Tissue perfusion was recorded non-touch in one point using a laser Doppler perfusion imager. During the measurements the object was placed on a shaker that generated the movement (both horizontal and vertical). Measurements were carried out both on DELRIN« (polyacetal plastic) and the fingertip, for a wide range of velocities (0-3 cm/s). The influence of the microvascular perfusion was evaluated by occluding the brachial artery as well as blood emptying the finger and by using a flow model. The LDF signals were correlated to the movement. In vivo measurements showed that velocities above 0.8 cm/s gave a significant contribution to the perfusion signal. Corresponding velocities for the DELRIN« piece were higher (1.4 - 2.6 cm/s), and dependent on the surface structures and reflecting properties. By reducing the amount of specular reflection the movement influence was substantially lowered.
Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2002. Vol. 4624, 106-114 p.
, Progress in Biomedical Optics and Imaging, ISSN 1605-7422
Medical Laboratory and Measurements Technologies
IdentifiersURN: urn:nbn:se:liu:diva-24552DOI: 10.1117/12.468313ISI: 000176856000013Local ID: 6712ISBN: 0819443638ISBN: 9780819443632OAI: oai:DiVA.org:liu-24552DiVA: diva2:244873
Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, San Jose, CA, USA January 19, 2002