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Titanium implants and BMP-7 in bone: An experimental model in the rabbit
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
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2003 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, Vol. 14, no 3, 247-254 p.Article in journal (Refereed) Published
Abstract [en]

This study evaluates the effect of rhBMP-7/OP-1 on the osseointegration of commercially pure titanium implants in an experimental implant model in rabbits. Threaded titanium implants with two transverse parallel canals were inserted in the femur and tibia of rabbits. The canals were filled with, 10 ╡g of BMP-7/collagen carrier, pure collagen carrier or were left empty as a control. The stiffness of the implant fixation was evaluated by Resonance Frequency Analysis (RFA) at baseline and four weeks postoperativly. Percentage of bone ingrowth in the canals was measured on microradiographs. Histomorphometry along the threaded part of the implants was performed on 15 ╡m thin sections. The results from the RFA demonstrated a higher mean value for the BMP-7 treated implants in the tibia than the carrier treated implants but not compared to the control implants. The control implants in the tibia demonstrated more bone ingrowth in the upper canal than to the carrier or the BMP-7 treated implants. Apart from these differences there were no significant effects of BMP. In this study BMP-7 did not contribute to any substantially improved bone anchorage of titanium implants.

Place, publisher, year, edition, pages
2003. Vol. 14, no 3, 247-254 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-24649DOI: 10.1023/A:1022884724059Local ID: 6877OAI: diva2:244971
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-13

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Aspenberg, Per
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Faculty of Health SciencesOrthopaedics and Sports MedicineDepartment of Orthopaedics Linköping
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Journal of materials science. Materials in medicine
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