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Immune activation in the small intestine in patients with rheumatoid arthritis
Dept of Molecular Medicine Helsinki, Finland.
Dept of Medicine Helsinki, Finland.
Dept of Surgery Helsinki, Finland.
Dept of Medicine Helsinki, Finland.
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2004 (English)In: Annals of the Rheumatic Diseases, ISSN 0003-4967, Vol. 63, no 10, 1327-1330 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: To determine whether inflammation in the gut associated immune system is activated in rheumatoid arthritis (RA). The expression of chemokine receptor- (CCR4, CCR5) and cytokine- (interleukin (IL)2, IL10, interferon γ (IFNγ), tumour necrosis factor α (TNFα), and transforming growth factor β (TGFβ)) specific mRNA in intestinal biopsy samples from patients with RA was examined. Methods: Duodenal biopsy samples from 13 patients with RA and 15 control subjects were studied. The mRNA expression of CCR4, CCR5, IL2, IL10, IFNγ, TNFα, and TGFβ in intestinal biopsy samples was demonstrated by real time quantitative reverse transcriptase-polymerase chain reaction. Results: The mRNA expression of CCR4, CCR5, and IL10 in intestinal biopsy samples was increased in patients with RA in comparison with control subjects (p = 0.001, p = 0.046, p = 0.019). No difference in the expression levels of IL2, IFNγ, TNFα, or TGFβ was seen between patients with RA and controls. Conclusions: The increased intestinal mRNA expression of IL10, CCR5, and CCR4 suggests that gut associated immune cells are activated in patients with RA.

Place, publisher, year, edition, pages
2004. Vol. 63, no 10, 1327-1330 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-24652DOI: 10.1136/ard.2003.011304Local ID: 6881OAI: oai:DiVA.org:liu-24652DiVA: diva2:244974
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

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Vaarala, Outi

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Faculty of Health SciencesPediatricsDepartment of Paediatrics in Linköping
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