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Parathyroid hormone - A drug for orthopedic surgery?
Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
2004 (English)In: Acta Orthopaedica Scandinavica, ISSN 0001-6470, Vol. 75, no 6, 654-662 p.Article in journal (Refereed) Published
Abstract [en]

Whereas continuous exposure to PTH results in bone resorption, administration at intermittent doses results in bone formation by increasing osteoblast number and activity. The anabolic action of PTH has also been demonstrated in clinical trials, in which PTH increased the bone mass and reduced fracture rate in patients with osteoporosis. In animal models of fracture healing and fixation of orthopedic implants, PTH increases the bone density in a dose-dependent manner, leading to faster repair and better fixation. The effect appears to be stronger on the new forming bone than on pre-existing bone. Based on these preclinical studies, we suggest that intermittent PTH treatment may also benefit fracture healing and implant fixation in patients.

Place, publisher, year, edition, pages
2004. Vol. 75, no 6, 654-662 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-24664DOI: 10.1080/00016470410004012Local ID: 6895OAI: diva2:244986
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

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Aspenberg, Per
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Faculty of Health SciencesOrthopaedics and Sports MedicineDepartment of Orthopaedics Linköping
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Acta Orthopaedica Scandinavica
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