liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes
Show others and affiliations
2004 (English)In: Diabetic Medicine, ISSN 0742-3071, Vol. 21, no 5, 447-455 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To identify clinical, immunological and biochemical factors that predict remission, and its duration in a large cohort of young adults with Type 1 diabetes mellitus (DM). Methods: In Sweden, 362 patients (15-34 years), classified as Type 1 DM were included in a prospective, nation-wide population-based study. All patients were followed at local hospitals for examination of HbA1c and insulin dosage over a median period after diagnosis of 5 years. Duration of remission, defined as an insulin maintenance dose ≤ 0.3 U/kg/24 h and HbA1c within the normal range, was analysed in relation to characteristics at diagnosis. Results: Remissions were seen in 43% of the patients with a median duration of 8 months (range 1-73). Sixteen per cent had a remission with a duration > 12 months. Among patients with antibodies (ab+), bivariate analysis suggested that adult age, absence of low BMI, high plasma C-peptide concentrations, lack of ketonuria or ketoacidosis at diagnosis and low insulin dose at discharge from hospital were associated with a high possibility of achieving remission. Multiple regression showed that normal weight (BMI of 20-24.9 kg/m2) was the only factor that remained significant for the possibility of entering remission. In survival analysis among ab+ remitters, a low number of islet antibodies, one or two instead of three or four, were associated with a long duration of remissions. Conclusion: In islet antibody-positive Type 1 DM, normal body weight was the strongest factor for entering remission, whilst a low number of islet antibodies was of importance for the duration.

Place, publisher, year, edition, pages
2004. Vol. 21, no 5, 447-455 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-24678DOI: 10.1111/j.1464-5491.2004.01175.xLocal ID: 6911OAI: diva2:245000
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Arnqvist, Hans
By organisation
Faculty of Health SciencesDivision of cell biologyDepartment of Endocrinology and Gastroenterology UHL
In the same journal
Diabetic Medicine
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 4 hits
ReferencesLink to record
Permanent link

Direct link