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Safety issues in assisted reproduction technology. Should ICSI patients have genetic testing before treatment? A practical proposition to help patient information
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
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2004 (English)In: Human Reproduction, ISSN 0268-1161, Vol. 19, no 3, 472-476 p.Article in journal (Refereed) Published
Abstract [en]

ICSI is a highly efficient treatment of male factor infertility and therefore increasingly used to treat infertile men successfully. However, when used to treat patients with a genetic cause for their infertility, there may be an increased risk for the offspring. Chromosome aberrations, Y chromosome microdeletions and CFTR (cystic fibrosis transmembrane conductance regulator) mutations alone may explain up to 25% of azoospermia and severe oligozoospermia. These genetic defects could be identified before treatment, in which case informed decisions could be made by the couple to be treated concerning the treatment, prenatal testing or preimplantation genetic diagnosis. Therefore, we propose that men with very low sperm counts (<5 × 106/ml) considering ICSI should always be informed of the possibility of genetic testing. The information should include a precise statement of the implications of the results for the patient, his family and his offspring, and reassurance that a decision to test or not to test, or the subsequent test results will not be used as a reason for withholding treatment. Testing should always remain voluntary, and the couples themselves should decide whether or not they choose to be tested. If an abnormality is identified, patients should be referred to specialist genetic counselling.

Place, publisher, year, edition, pages
2004. Vol. 19, no 3, 472-476 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-24694DOI: 10.1093/humrep/deh100Local ID: 6931OAI: diva2:245016
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-12

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Selbing, Anders
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Faculty of Health SciencesObstetrics and gynecologyDepartment of Gynecology and Obstetrics in Linköping
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Human Reproduction
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