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Evaluation of new antiemetic agents and definition of antineoplastic agent emetogenicity-an update
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2005 (English)In: Supportive Care in Cancer, ISSN 0941-4355, Vol. 13, no 2, 80-84 p.Article in journal (Refereed) Published
Abstract [en]

Development of effective antiemetic therapy depends upon an understanding of both the antiemetic agents and the emetogenic challenges these agents are designed to address. New potential antiemetic agents should be studied in an orderly manner, proceeding from phase I to phase II open-label trials and then to randomized double-blind phase III trials comparing new agents and regimens to best standard therapy. Use of placebos in place of antiemetic therapy against highly or moderately emetogenic chemotherapy is unacceptable. Nausea and vomiting should be evaluated separately and for both the acute and delayed periods. Defining the emetogenicity of new antineoplastic agents is a challenge, since such data are often not reliably recorded during early drug development. A four-level classification system is proposed for emetogenicity of intravenous antineoplastic agents. A separate four-level classification system for emetogenicity of oral antineoplastic agents, which are often given over an extended period of time, is also proposed.

Place, publisher, year, edition, pages
2005. Vol. 13, no 2, 80-84 p.
Keyword [en]
antiemetic, emetogenicity, emesis, nausea, classification
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-24761DOI: 10.1007/s00520-004-0718-yLocal ID: 7021OAI: diva2:245084
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2013-09-03

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Börjeson, Sussanne
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Faculty of Health SciencesNursing ScienceDepartment of Oncology UHL
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