Is vascular reactivity in skin predictable?
2000 (English)In: Skin research and technology, ISSN 0909-752X, Vol. 6, no 1, 27-30 p.Article in journal (Refereed) Published
Background/aims: Cutaneous microdialysis can be used to follow the pharmacology and metabolism of an inflammatory reaction. It is assumed that an equilibration period compensates for the trauma of catheter insertion. Methods: In the present paper, the vascular reactivity of the skin to histamine was tested using assessment by laser Doppler perfusion imaging. In a group of six subjects, the provocation was preceded by insertion of a microdialysis catheter. In a second control group, histamine provocation alone was performed (six subjects). Results: The vascular response to histamine was greater in the microdialysis catheter group than the control group. The histamine provocation caused a greater response than catheter insertion. Further, there was a correlation between the response to catheter insertion and the histamine provocation. Conclusion: It appears that the insertion and/or presence of a microdialysis catheter increases vascular reactivity to subsequent provocation. The response to catheter insertion may predict skin reactivity in general in the individual subject. (C) Munksgaard, 2000.
Place, publisher, year, edition, pages
2000. Vol. 6, no 1, 27-30 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-24848DOI: 10.1034/j.1600-0846.2000.006001027.xLocal ID: 9247OAI: oai:DiVA.org:liu-24848DiVA: diva2:245171