Developing chicken oligodendrocytes express the type IV oligodendrocyte marker T4-O in situ, but not in vitro
2000 (English)In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 284, no 1-2, 21-24 p.Article in journal (Refereed) Published
Accumulating data suggest that the oligodendrocyte population includes morphological and biochemical subtypes. We recently reported that a polyclonal antiserum against an unknown antigen, the T4-O molecule, labels a subpopulation of chicken oligodendrocytes, obviously representing the type IV variety of Del Rio Hortega. The present study examines the developmental expression of the T4-O molecule in situ and in vitro. The results show that T4-O immunoreactive cells first appear at E15 in the ventral funiculus. But, oligodendrocytes cultured in vitro with or without neurones do not develop a T4-O immunoreactivity. We conclude that oligodendrocytes in the spinal cord of chicken embryos first express the T4-O molecule some time after onset of myelination, and that the T4-O immunoreactive phenotype does not develop in vitro.
Place, publisher, year, edition, pages
2000. Vol. 284, no 1-2, 21-24 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-24853DOI: 10.1016/S0304-3940(00)00989-7Local ID: 9253OAI: oai:DiVA.org:liu-24853DiVA: diva2:245176