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Instrumental and dermatologist evaluation of the effect of glycerine and urea on dry skin in atopic dermatitis
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Dermatology. Östergötlands Läns Landsting, Centre for Medicine, Department of Dermatology and Venerology in Östergötland.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Dermatology. Östergötlands Läns Landsting, Centre for Medicine, Department of Dermatology and Venerology in Östergötland.
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2001 (English)In: Skin research and technology, ISSN 0909-752X, E-ISSN 1600-0846, Vol. 7, no 4, 209-213 p.Article in journal (Refereed) Published
Abstract [en]

Background/aims: Moisturising creams are useful treatment adjuncts in inflammatory dermatoses and have beneficial effects in the treatment of dry, scaly skin. The effects on dryness and skin permeability of a new moisturising cream with 20% glycerine was compared with its placebo and with a medicinally authorised cream with 4% urea (combined with 4% sodium chloride) in the treatment of dry skin. Methods: Patients (n=109) with atopic dermatitis were treated for 30 days with a moisturiser in a randomised, parallel and double-blind fashion. Transepidermal water loss (TEWL) and skin capacitance were assessed instrumentally, and changes in the dryness of the skin were assessed by the dermatologist. Results: No difference in TEWL was found between glycerine treatment and its placebo, whereas a lower value was found in the urea-treated area compared to the glycerine-treated area. No difference in skin capacitance was found. The clinical assessment of dryness showed urea to be superior to glycerine in treating the condition. Conclusions: Moisturising creams are different, not only with respect to composition but also with respect to their influence on skin as a barrier to water in patients with atopic dermatitis.

Place, publisher, year, edition, pages
2001. Vol. 7, no 4, 209-213 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-24866DOI: 10.1034/j.1600-0846.2001.070401.xLocal ID: 9268OAI: oai:DiVA.org:liu-24866DiVA: diva2:245189
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13

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Andersson, ChrisFrödin, ThomasÖhman, Hans

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Andersson, ChrisFrödin, ThomasÖhman, Hans
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Faculty of Health SciencesDermatologyDepartment of Dermatology and Venerology in Östergötland
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