Instrumental and dermatologist evaluation of the effect of glycerine and urea on dry skin in atopic dermatitis
2001 (English)In: Skin research and technology, ISSN 0909-752X, Vol. 7, no 4, 209-213 p.Article in journal (Refereed) Published
Background/aims: Moisturising creams are useful treatment adjuncts in inflammatory dermatoses and have beneficial effects in the treatment of dry, scaly skin. The effects on dryness and skin permeability of a new moisturising cream with 20% glycerine was compared with its placebo and with a medicinally authorised cream with 4% urea (combined with 4% sodium chloride) in the treatment of dry skin. Methods: Patients (n=109) with atopic dermatitis were treated for 30 days with a moisturiser in a randomised, parallel and double-blind fashion. Transepidermal water loss (TEWL) and skin capacitance were assessed instrumentally, and changes in the dryness of the skin were assessed by the dermatologist. Results: No difference in TEWL was found between glycerine treatment and its placebo, whereas a lower value was found in the urea-treated area compared to the glycerine-treated area. No difference in skin capacitance was found. The clinical assessment of dryness showed urea to be superior to glycerine in treating the condition. Conclusions: Moisturising creams are different, not only with respect to composition but also with respect to their influence on skin as a barrier to water in patients with atopic dermatitis.
Place, publisher, year, edition, pages
2001. Vol. 7, no 4, 209-213 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-24866DOI: 10.1034/j.1600-0846.2001.070401.xLocal ID: 9268OAI: oai:DiVA.org:liu-24866DiVA: diva2:245189