Effects of cholecystokinin on acid formation in glands and cells isolated from rabbit and rat gastric mucosa
2000 (English)In: Comparative Biochemistry and Physiology A, ISSN 1095-6433, E-ISSN 1531-4332, Vol. 126, no 1, 77-84 p.Article in journal (Refereed) Published
Isolated gastric glands and isolated cells prepared from rabbit and rat were studied to analyse the influence of cholecystokinin octapeptide (CCK 8) on histamine stimulated parietal cell acid formation as assessed by [14C]aminopyrine sequestered in acid tissue compartments. In rabbit gastric glands, CCK 8 evoked 32±6% (P<0.01) inhibition of histamine stimulated acid formation, whereas in glands prepared from rat no inhibition was recorded. Instead, CCK 8 seemed to induce a variable increase of the histamine stimulation in rat gastric glands as the aminopyrine accumulation was increased by 110±46% (P<0.1). Further studies on cell preparations derived from rabbit gastric mucosa revealed dual properties of CCK 8, eliciting either inhibition or stimulation of the parietal cell depending on the presence of endocrine cells. The results show that paracrine communication may be effective in glandular preparations, but seems to vary depending on species.
Place, publisher, year, edition, pages
2000. Vol. 126, no 1, 77-84 p.
Inhibition of acid, Acid secretion, Fundic glands, In vitro, Paracrine function, Parietal cells, Histamine stimulation, Somatostatin
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-24925DOI: 10.1016/S1095-6433(00)00188-4PubMedID: 10908854Local ID: 9330OAI: oai:DiVA.org:liu-24925DiVA: diva2:245249