Association of breast cancer progression with a vitamin D receptor gene polymorphism
1999 (English)In: Cancer Research, ISSN 0008-5472, E-ISSN 1538-7445, Vol. 59, no 10, 2332-2334 p.Article in journal (Refereed) Published
The vitamin D3 receptor gene (VDR) contains a TaqI RFLP that is associated with increased VDR mRNA stability, increased serum levels of 1α,25-dihydroxyvitamin D3 (1,25-D3), and decreased risk for prostate cancer. Determination of the TaqI genotype, in a group of young women with breast cancer (n = 111; age, <37 years) and a control population (n = 130), revealed no overall association to risk for breast cancer. However, patients without TaqI site (TT genotype) showed a significantly increased risk for lymph node metastasis (relative risk, 1.8, 95% confidence interval, 1.3- 2.6). Furthermore, a tendency toward an increased survival was found among estrogen receptor-positive, tamoxifen-treated patients who were homozygous for the TaqI site (P = 0.075). We conclude that polymorphism in the VDR gene may influence tumor progression and tamoxifen treatment response in early- onset breast carcinomas.
Place, publisher, year, edition, pages
1999. Vol. 59, no 10, 2332-2334 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-24934PubMedID: 10344739Local ID: 9340OAI: oai:DiVA.org:liu-24934DiVA: diva2:245258