Expression of leukotriene C4 synthase mRNA by the choroid plexus in mouse brain suggests novel neurohormone functions of cysteinyl leukotrienes
2003 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 307, no 4, 987-990 p.Article in journal (Refereed) Published
Leukotriene C4 is a potent mediator of allergic and inflammatory reactions, and is formed from arachidonic acid and glutathione through the sequential action of 5-lipoxygenase and leukotriene C4 synthase (LTCS). These enzymes are predominantly expressed in cells of myeloid lineage. In this report, we have investigated LTCS mRNA expression in mouse brain. Expression was demonstrated using RT-PCR and RNase protection assays. In situ hybridization experiments showed exclusive staining of the choroid plexus of all brain ventricles. This expression pattern may provide a mechanism for the generation of LTC4 on the cerebral side of the blood-brain barrier and suggests a possible novel regulator function of LTC4 in the formation of cerebrospinal fluid.
Place, publisher, year, edition, pages
2003. Vol. 307, no 4, 987-990 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-24952DOI: 10.1016/S0006-291X(03)01306-8ISI: 000184510100036Local ID: 9363OAI: oai:DiVA.org:liu-24952DiVA: diva2:245276