Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis
2003 (English)In: Nature Neuroscience, ISSN 1097-6256, Vol. 6, no 11, 1137-1138 p.Article in journal (Refereed) Published
We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain endothelial cells. These animals showed no fever and no central prostaglandin (PG) E2 synthesis after peripheral injection of bacterial-wall lipopolysaccharide, but their pyretic capacity in response to centrally administered PGE2 was intact. Our findings identify mPGES-1 as the central switch during immune-induced pyresis and as a target for the treatment of fever and other PGE2-dependent acute phase reactions elicited by the brain.
Place, publisher, year, edition, pages
2003. Vol. 6, no 11, 1137-1138 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-24954DOI: 10.1038/nn1137Local ID: 9365OAI: oai:DiVA.org:liu-24954DiVA: diva2:245278