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Inhibitory effect of diabetes on proliferation of vascular smooth muscle after balloon injury in rat aorta
Linköping University, Department of Biomedicine and Surgery, Cell biology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Biomedicine and Surgery, Cell biology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Neuroscience and Locomotion, Pathology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medicine and Care, Internal Medicine. Östergötlands Läns Landsting, MKC-2, GE: endomed. Linköping University, Faculty of Health Sciences.
2000 (English)In: Experimental Diabetes Research, ISSN 1687-5214, E-ISSN 1687-5303, Vol. 1, no 2, 101-109 p.Article in journal (Refereed) Published
Abstract [en]

The effect of streptozotocin-induced diabetes on cell proliferation in rat aortic intima-media, as well as on local gene expression of transforming growth factor-β1 (TGF-β1) was studied. TGF-β1 mRNA was measured by solution hybridization and TGF-β1 protein by ELISA. Proliferation was measured by bromodeoxyuridine incorporation into DNA two days after balloon injury. All BrdU-labelled cells observed were smooth muscle cells. After a diabetes duration of 2 and 4 weeks, labelled cells were significantly fewer compared with controls. Circulating levels of total TGF-β1 were lowered in rats with 2 weeks diabetes. Although the balloon injury procedure by itself stimulated the gene expression of TGF-β1, no significant difference in TGF-β1 mRNA content between diabetic and control rats after injury was found. In conclusion: vascular smooth muscle proliferation in vivo is inhibited by the diabetic state in this model of insulin deficient diabetes and this inhibition is not related to an impaired local expression of TGF-β1.

Place, publisher, year, edition, pages
2000. Vol. 1, no 2, 101-109 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-24975DOI: 10.1155/EDR.2000.101PubMedID: 11469394Local ID: 9386OAI: oai:DiVA.org:liu-24975DiVA: diva2:245299
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13

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Gustafsson, BertilArnqvist, Hans

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Cell biologyFaculty of Health SciencesPathologyDepartment of Clinical Pathology and Clinical GeneticsInternal MedicineGE: endomed
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Experimental Diabetes Research
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