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Morphological examination of the termination pattern of substance P-immunoreactive nerve fibers in human antral mucosa
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Cell biology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Internal Medicine. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Acute Internal Medicine.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Cell biology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Cell biology.
2002 (English)In: Regulatory Peptides, ISSN 0167-0115, Vol. 107, no 1-3, 79-86 p.Article in journal (Refereed) Published
Abstract [en]

The termination pattern of substance P (SP)-containing axons in human antral mucosa was examined using immunohistochemical techniques at the light and electron microscopic level. SP-immunoreactive (IR) axons were found to extend towards the pit region of the glands, where intraepithelial axons were observed. Electron microscopy showed immunostained axon profiles in close contact with the basement membrane of surface mucous cells. Membrane-to-membrane contacts between labeled axons and myofibroblast-like cells were identified, and SP-IR axons that were apposed to the epithelium were also in contact with subjacent myofibroblast-like cells. The anatomical relationship between SP-IR axons and the cells of the muscularis mucosae was investigated by light microscopy. Immunoreactivity for a-smooth muscle actin (a-sma) was used to visualize the smooth muscle cells, and the a-sma-IR cells were found to create a network that surrounded the gastric glands. Immunostained varicose axons ran alongside and in close apposition to the labeled muscle strands. Ultrastructural examination showed close contacts between SP-IR axon profiles and smooth muscle-like cells. In conclusion, SP-containing neurons may be important for sensory and secretomotor functions in the human antral mucosa.

Place, publisher, year, edition, pages
2002. Vol. 107, no 1-3, 79-86 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-25004DOI: 10.1016/S0167-0115(02)00066-6Local ID: 9425OAI: oai:DiVA.org:liu-25004DiVA: diva2:245328
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-13

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Ericson, Ann-CharlottKechagias, StergiosÖqvist, GunillaSjöstrand, Sven-Erik

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