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A new functional classification of tumor-suppressing genes and its therapeutic implications
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Cell biology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Cell biology.
2000 (English)In: Bioessays, ISSN 0265-9247, E-ISSN 1521-1878, Vol. 22, no 3, 274-285 p.Article in journal (Refereed) Published
Abstract [en]

Cell fusion studies have demonstrated that malignancy can be suppressed by a single dose of malignancy suppressor genes (MSGs), indicating that malignancy is a recessive phenotype. Correspondingly, it is widely believed that mutational inactivation of both alleles of tumor suppressor genes (TSGs), in familial and sporadic tumors, is the formal proof of the recessive nature of malignancy. Evidence presented here, however, shows that unlike MSGs, identified solely through cell fusion studies with no gene of this class yet cloned, many well-known TSGs have gene dosage effects and inhibit cellular growth in vitro. Moreover, homozygous inactivation of a growth-inhibitory TSG (GITSG) is not directly correlated with malignancy. An alternative interpretation is provided for the loss of wild-type alleles of these genes in the tumors. It is concluded that the MSGs and the GITSGs do not belong to the same class of genes. The functional classification of tumor-suppressing genes has important implications for developing effective cancer therapies. (C) 2000 John Wiley and Sons, Inc.

Place, publisher, year, edition, pages
2000. Vol. 22, no 3, 274-285 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-25106DOI: 10.1002/(SICI)1521-1878(200003)22:3<274::AID-BIES9>3.0.CO;2-GLocal ID: 9538OAI: oai:DiVA.org:liu-25106DiVA: diva2:245432
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13

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Islam, QuamrulIslam, Khaleda

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