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Comparison of ethanol concentrations in venous blood and end-expired breath during a controlled drinking study
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Clinical Chemistry.
2003 (English)In: Forensic Science International, ISSN 0379-0738, E-ISSN 1872-6283, Vol. 132, no 1, 18-25 p.Article in journal (Refereed) Published
Abstract [en]

Concentration-time profiles of ethanol were determined for venous whole blood and end-expired breath during a controlled drinking experiment in which healthy men (n=9) and women (n=9) drank 0.40-0.65g ethanol per kg body weight in 20-30min. Specimens of blood and breath were obtained for analysis of ethanol starting at 50-60min post-dosing and then every 30-60min for 3-6h. This protocol furnished 130 blood-breath pairs for statistical evaluation. Blood-ethanol concentration (BAC, mg/g) was determined by headspace gas chromatography and breath-ethanol concentration (BrAC, mg/2l) was determined with a quantitative infrared analyzer (Intoxilyzer 5000S), which is the instrument currently used in Sweden for legal purposes. In 18 instances the Intoxilyzer 5000S gave readings of 0.00mg/2l whereas the actual BAC was 0.08mg/g on average (range 0.04-0.15mg/g). The remaining 112 blood- and breath-alcohol measurements were highly correlated (r=0.97) and the regression relationship was BAC=0.10+0.91BrAC and the residual standard deviation (S.D.) was 0.042mg/g (8.4%). The slope (0.91▒0.0217) differed significantly from unity being 9% low and the intercept (0.10▒0.0101) deviated from zero (t=10.2, P0.05). The mean rate of ethanol disappearance from blood was 0.157▒0.021mg/(g per hour), which was very close to the elimination rate from breath of 0.161▒0.021mg/(2l per hour) (P>0.05). Breath-test results obtained with Intoxilyzer 5000S (mg/2l) were generally less than the coexisting concentrations of ethanol in venous blood (mg/g), which gives an advantage to the suspect who provides breath compared with blood in cases close to a threshold alcohol limit. ⌐ 2002 Elsevier Science Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
2003. Vol. 132, no 1, 18-25 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-25128DOI: 10.1016/S0379-0738(02)00417-6Local ID: 9561OAI: diva2:245454
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2012-03-21

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