liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
The value of cysteinyldopa in the follow-up of disseminated malignant melanoma
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Clinical Chemistry. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Chemistry.
Show others and affiliations
2000 (English)In: Melanoma research, ISSN 0960-8931, Vol. 10, no 4, 363-369 p.Article in journal (Refereed) Published
Abstract [en]

In a series of 92 patients with malignant melanoma, clinical stage III or IV, both 5-S-cysteinyldopa (5SCD) and 6-hydroxy-5-methoxyindole-2-carboxylic acid (6H5MI2C) were measured in urine during chemotherapy. A total of 434 urine specimens were analysed. The sensitivity of 5SCD for the detection of stage III-IV melanoma was 83%, while the corresponding sensitivity of 6H5MI2C was 52%. Fifty per cent of patients with one metastatic site had increased 5SCD excretion, while all patients with four or more metastatic sites had increased excretion. A significant correlation was found between 5SCD decrease and clinical regression (P < 0.001) and between 5SCD increase and clinical progression (P < 0.001). Corresponding correlations were not found for 6H5MI2C. Increments in 5SCD excretion (median 269 ╡mol/mol creatinine) were seen for 83% of the occasions when clinical progression was recorded, and decrements in 5SCD excretion (median 145 ╡mol/mol creatinine) were seen for 85% of the occasions when clinical regression was seen. During clinical 'stable disease' increases in 5SCD excretion were seen in 59% and decreases in 41%. The median value of 5SCD changes for stable disease was 7.0 ╡mol/mol creatinine, indicating a chemical marker stability in many cases. We recommend the use of 5SCD in urine as a valuable, reliable and simple biochemical marker to use in the clinical follow-up of melanoma patients with advanced disease.

Place, publisher, year, edition, pages
2000. Vol. 10, no 4, 363-369 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-25195DOI: 10.1097/00008390-200008000-00008Local ID: 9634OAI: diva2:245522
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-14

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Kågedal, BertilÅrstrand, Kerstin
By organisation
Faculty of Health SciencesClinical ChemistryDepartment of Clinical Chemistry
In the same journal
Melanoma research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 14 hits
ReferencesLink to record
Permanent link

Direct link