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Effects of inhalation of corticosteroids immediately after experimental chlorine gas lung injury
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Anaesthesiology. Östergötlands Läns Landsting, Heart Centre, Department of Thoracic and Vascular Surgery.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Surgery. Östergötlands Läns Landsting, MKC-2, GE: Gastrokir.
2000 (English)In: Journal of Trauma - Injury, Infection and Critical Care, ISSN 1079-6061, Vol. 48, no 1, 101-107 p.Article in journal (Refereed) Published
Abstract [en]

Background: To assess the effects of treatment with nebulized corticosteroids immediately after chlorine gas injury. Methods: Eighteen anesthetized and mechanically ventilated pigs were exposed to chlorine gas (140 ppm for 10 minutes) and observed for 6 hours. Nine pigs were treated with nebulized beclomethasone-dipropionate 20 ╡g/kg (BDP group), and nine pigs were given no treatment (control group). Results: All animals developed severe pulmonary dysfunction. The initial decrease in PaO2 was similar in both groups, but BDP-treated animals improved whereas control animals deteriorated (p < 0.005, analysis of variance). Pulmonary vascular resistance increased in both groups but less in the BDP group (p < 0.01). Lung-thorax compliance was better preserved in the BDP group (p < 0.01), and oxygen delivery was significantly better in the BDP group (p < 0.01). One animal died in the BDP group, as did three animals in the control group. Conclusion: Immediate treatment with nebulized BDP improved pulmonary and cardiovascular function after experimental chlorine gas injury.

Place, publisher, year, edition, pages
2000. Vol. 48, no 1, 101-107 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-25214Local ID: 9653OAI: diva2:245541
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-14

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Walther, StenLennquist, Sten
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Faculty of Health SciencesAnaesthesiologyDepartment of Thoracic and Vascular SurgerySurgeryGE: Gastrokir
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