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A critical evaluation of the prothrombin time for monitoring oral anticoagulant therapy
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Clinical Chemistry. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Chemistry.
2003 (English)In: Pathophysiology of Haemostasis and Thrombosis, ISSN 1424-8832, Vol. 33, no 1, 43-51 p.Article in journal (Refereed) Published
Abstract [en]

The Quick prothrombin time is the most common clotting test performed, principally for monitoring oral anticoagulant therapy. The International Normalized Ratio (INR) for comparing patient results from prothrombin time measurements and the International Standardized Index (ISI) for achieving greater consistency of results using different thromboplastins have made it possible to compare the results of vitamin K antagonist drug therapy that was impossible before the introduction of the INR and ISI. However, INR values obtained from the same patient plasma sample using different thromboplastins are significantly different. This is so even when the thromboplastins have nearly the same ISI values. We suggest that investigation of patient-specific differences can provide a means by which the INR discrepancies can be identified and understood and thus lead to better methods for monitoring oral anticoagulant therapy.

Place, publisher, year, edition, pages
2003. Vol. 33, no 1, 43-51 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-25240DOI: 10.1159/000071641Local ID: 9679OAI: diva2:245567
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-13

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Lindahl, Tomas
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Faculty of Health SciencesClinical ChemistryDepartment of Clinical Chemistry
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