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ADP activation induces bFGF binding to platelets in vitro
Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Clinical Chemistry. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Chemistry.
2002 (English)In: Uppsala Journal of Medical Sciences, ISSN 0300-9734, Vol. 107, no 3, 165-171 p.Article in journal (Refereed) Published
Abstract [en]

Basic fibroblast growth factor (bFGF), is a heparin-binding factor with potent angiogenic properties in vitro and in vivo. bFGF is involved in tumour growth, but it has also been shown to reduce infarct size in experimentally induced acute myocardial infarction. Platelets are also believed to have an important role in both tumour growth and myocardial infarction. We have studied bFGF binding to platelets by flow cytometry. Platelet activation by ADP induces bFGF binding to platelets. bFGF bound to activated platelets will result in a locally high concentration of bFGF in patients with myocardial infarctions and malignant tumours. Addition of recombinant bFGF to platelet rich plasma reduced the percentage of fibrinogen positive platelets. bFGF may thus have an inhibitory effect on platelet aggregation.

Place, publisher, year, edition, pages
2002. Vol. 107, no 3, 165-171 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-25247Local ID: 9686OAI: diva2:245575
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-13

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Lindahl, Tomas
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